Description
Variant D is a non-depleting IgG1 monoclonal antibody variant with amino acid substitutions N297A, N434H in the heavy chain to increase serum half life. This antibody can be used for treating autoimmune disorders in mammalian subjects.
Target
CD4
Target Alias Names
CD4 Molecule, T-Cell Surface Glycoprotein CD4, T-Cell Surface Antigen T4/Leu-3, CD4 Antigen (P55), CD4 Receptor, CD4 Antigen, CD4mut
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression