Description
Recombinant Human Antibody (576) is capable of binding to CD4, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CD4 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CD4 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This is a potent broadly neutralizing CD4-binding-site antibody that mimic binding to CD4.
Target
CD4
Target Alias Names
CD4, CD4 molecule, CD4mut, T-cell surface glycoprotein CD4, CD4 receptor, CD4 antigen (p55), T-cell surface antigen T4Leu-3
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression