Description
The product is a fullly human antibody targets for CD38. In the inhibition assay, the antibody binds to recombinant human CD38 protein at a concentration of 3 μg/mL. The release of soluble protein and the ability to internalize membrane-bound proteins indicate extracellular and intracellular functions of the protein. Diseases associated with CD38 include prolymphocytic leukemia and chronic lymphocytic leukemia 2.
Target
CD38
Target Alias Names
CD38 Molecule, ADP-Ribosyl Cyclase 1, 2-Phospho-Cyclic-ADP-Ribose Transferase, Cyclic ADP-Ribose Hydrolase 1, 2-Phospho-ADP-Ribosyl Cyclase, NAD(+) Nucleosidase, CD38 Antigen (P45), ADPRC 1, 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase, Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase, Cluster Of Differentiation 38, CADPr Hydrolase 1, CD38 Antigen, EC 2.4.99.20, EC 3.2.2.6, ADPRC1, T10
Isotypes/Mimetics
Human IgG1, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression