Description
HPAB-1045-FY is a recombinant humanized antibody that targets CD37. The humanized versions of HPAB-1045-FY display comparable binding to Ramos cells as the original antibody, suggesting that humanization does not diminish its ability to bind to the CD37 antigen on cells. Humanized anti-CD37 antibodies, along with pharmaceutical compositions incorporating them, have proven to be beneficial for treating B cell malignancies, as well as autoimmune and inflammatory diseases that involve B cells in their pathology.
Target
CD37
Target Alias Names
CD37 Molecule, Tetraspanin-26, CD37 Antigen, Tspan-26, TSPAN26, Cell Differentiation Antigen 37, Leukocyte Surface Antigen CD37, Leukocyte Antigen CD37, GP52-40
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression