Description
HuM291-Fos inhibits the binding of FITC-labeled murine M291 IgG2a and unlabeled M291. The affinity of HuM291 for CD3 is estimated to be approximately 2-3 times that of M291. Scatchard analysis revealed that the apparent affinity of HuM291-Fos was approximately Ka=1.1 nM.
Target
CD3
Target Alias Names
CD3E, CD3e molecule, epsilon (CD3-TCR complex), T3E, TCRE, IMD18, T-cell surface glycoprotein CD3 epsilon chain, CD3-epsilon, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e antigen, epsilon polypeptide (TiT3 complex), T-cell antigen receptor complex, epsilon subunit of T3
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression