Description
Provided is an aglycosylated humanized anti-C3b (AAC3b) antibody. AAC3b antibodies described herein can recognize C3b with high affinity without any change in the functional activity. The AAC3b and AC3b antibodies are capable of inhibiting the interaction between C3b and factor B. The AAC3b and AC3b antibodies do not inhibit properdin binding to C3b. Both antibodies can demonstrate comparable activity in a variety of alternative complement assays.
Target
C3b
Target Alias Name
Complement component 3b
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression