Description
Recombinant Human Antibody (9TL) is capable of binding to APP, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-APP mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-APP mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. It binds specifically to the carboxyl (C)-terminus of Aβ40.
Target
APP
Target Alias Names
AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma
Isotypes/Mimetics
Human IgG2, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression