Description
Amongst the CrossMab alternatives published (CrossMabCH1CL, CrossMabVHVL and CrossMabFab), the CrossMabCH1CL is preferred due to its theoretical side product profile that was confirmed when the different CrossMabs were expressed in parallel and analyzed for their side purity [16]. The approach chosen and in particular the elbow region in the CrossMabCH1CL allows correct chain association and generation of a functional antibody as predicted. The CrossMAb approach represents a viable option for the generation of human bispecific heterodimeric IgG antibodies of different isotypes.
Target
ANGPT2
Target Alias Names
Angiopoietin 2, ANG-2, Angiopoietin-2B, Angiopoietin-2a, Angiopoietin-2, Tie2-Ligand, AGPT2, ANG2
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression