Description
The humanized antibody derived from murine clone B9 binds to a human αv subunit-containing heterodimeric integrin receptors. B9 binds to cells expressing αv β3 and αv β5. Flow cytometry using human smooth muscle cells (SMC) indicated that mAb B9 has great capacity to bind to a native receptor on the cell surface.
Target
αv β3 and αv β5
Target Alias Names
Integrin αv β3, Integrin αv β5
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression