Description
Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma.Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity,with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities.Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissuessuch as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signalingthrough a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissueremodeling by binding and sequestering various growth factors with distinct binding affinities, depending on thetype of complex: LMW, MMW or HMW.
Target
Adiponectin
Isotype/Mimetic
Mouse IgG1
Animal-Derived Biomaterials Used
No
Sequence Available
Yes
Original Discovery Method
Antibody display library from animal blood draw
Antibody/Binder Origins
Animal-dependent discovery (in vitro display, OR immunisation pre-2020), Unknown discovery source/method, In vitro recombinant expression