Description
Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. B6R is a host-range protein that is located on the membrane of the outer envelope EEV (EEV), is homologous to the vaccinia virus complement control protein B5, and is involved in the negative regulation of complement activation.B5R is the most frequent target of host-neutralizing antibodies.B5R is a 42-kDa envelope glycoprotein containing four short consensus repeat (SCR) domains, whose expression is critical for viral morphogenesis, trafficking, dissemination, and EEV production. B5 is conserved among different orthopoxviruses and B5 antibodies protect the host from vaccinia virus challenge. B5 antibody can neutralize vaccinia EVs, and the mechanism is unclear.
Target
MPXV B6R
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
No
Sequence Available
Yes
Original Discovery Method
Unknown
Antibody/Binder Origins
Animal-free discovery, Unknown discovery source/method, In vitro recombinant expression, Animal-derived biomaterials used in production or final formulation