Description
Recombinant monoclonal antibody to erbB-2 (Her-2/neu). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody 4D5-8 (trastuzumab). This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against human HER2 (Fab) and one arm directed against mouse CD3e (scFv).
Target
erbB-2 (Her-2/neu)
Target Alias Names
CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR
Isotype/Mimetic
IgG2a mCD3e KIH bispecific
Animal-Derived Biomaterials Used
No
Sequence Available
No
Original Discovery Methods
Naïve display libraries derived from human B cells, or naïve display libraries from animal B cells or Display libraries from synthetic or natural framework sequences
Original Discovery Information Provided On Datasheet
Yes
Antibody/Binder Origins
Animal-free discovery, Animal-dependent discovery (in vitro display, OR immunisation pre-2020), In vitro recombinant expression