Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Implicated in head and neck squamous cell carcinoma and melanoma. Biomarker of gastrointestinal system cancer (multiple), lung non-small cell carcinoma, and lymphoma (multiple). [provided by Alliance of Genome Resources, Jul 2025]
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