Description
Provided are fully human monoclonal antibodies that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. The antibody can be used for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.
Target
NOTCH1
Target Alias Names
Notch 1, Translocation-Associated Notch Protein TAN-1, TAN1, HN1, Notch (Drosophila) Homolog 1 (Translocation-Associated), Notch Homolog 1, Translocation-Associated (Drosophila), Notch Homolog 1, Translocation-Associated
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression