Description
Provided is a novel isolated antibody (clone hz515 VH1 D76N VL2.2) capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and able to inhibit HIV-1 primary isolate replication in PBMC.
Target
CXCR4
Target Alias Names
C-X-C Motif Chemokine Receptor 4, Leukocyte-Derived Seven Transmembrane Domain Receptor, Lipopolysaccharide-Associated Protein 3, Stromal Cell-Derived Factor 1 Receptor, Chemokine (C-X-C Motif) Receptor 4, LPS-Associated Protein 3, SDF-1 Receptor, CD184 Antigen, Fusin, LAP-3, LESTR, NPYRL, FB22, HM89, LCR1, Seven-Transmembrane-Segment Receptor, Spleen, Chemokine (C-X-C Motif), Receptor 4 (Fusin)
Isotype/Mimetic
Humanized (mouse/human) IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression