Description
Recombinant Human Antibody (mAb1) is capable of binding to ECD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ECD mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ECD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody inhibits glucagon receptor by occluding a surface extending across the entire hormone-binding cleft.
Target
ECD
Target Alias Names
ECD, ecdysoneless homolog (Drosophila), GCR2, HSGT1, protein SGT1, suppressor of GCR2, protein ecdysoneless homolog, suppressor of S. cerevisiae gcr2
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression