Description
Recombinant Human Antibody (CNTO 888) is capable of binding to CCL2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CCL2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CCL2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody binds CCL2 with high affinity (KD = 22 pM) and inhibits CCL2 binding to its receptor and consequentfunctional activity.
Target
CCL2
Target Alias Names
CCL2, chemokine (C-C motif) ligand 2, HC11, MCAF, MCP1, MCP-1, SCYA2, GDCF-2, SMC-CF, HSMCR30, C-C motif chemokine 2, small-inducible cytokine A2, monocyte secretory protein JE, monocyte chemotactic protein 1, monocyte chemoattractant protein 1, monocyte chemoattractant protein-1, monocyte chemotactic and activating factor, small inducible cytokine subfamily A (Cys-Cys), member 2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression