Description
Autoimmune reactions to certain epitopes of self antigens most likely contribute to the development of rheumatoid arthritis. Often these epitopes are citrullinated. Provided is a novel antibody G12 that can bind to certain citrullinated epitopes namely citrullinated enolase, vimentin, fibrinogen and citrullinated synthetic peptides. The antibody may also be an antibody that binds to only CEP-l and CCP such at least one antibody selected from the group consisting of B05, C05 C04 and G12. The antibody can be used in diagnostics of rheumatoid arthritis, for therapy against rheumatoid arthritis and as research tools.
Target
Citrullinated epitope
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression