Description
Recombinant Human Antibody (S77) is capable of binding to C3b, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-C3b mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-C3b proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody blocks binding of factor B to C3b inhibiting the first step in the formation of the alternative pathway C3 convertase.
Target
C3b
Target Alias Names
C3, complement component 3, ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, complement C3, prepro-C3, C3a anaphylatoxin, complement component C3, complement component C3a, complement component C3b, acylation-stimulating protein cleavage product, epididymis secretory sperm binding protein Li 62p, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression