Description
Recombinant Human Antibody (A2) is capable of binding to TNFA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TNFA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TNFA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
TNF
Target Alias Names
TNF, tumor necrosis factor, DIF, TNFA, TNFSF2, TNF-alpha, TNF-a, cachectin, APC1 protein, TNF, monocyte-derived, TNF, macrophage-derived, tumor necrosis factor-alpha, tumor necrosis factor ligand superfamily member 2
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression