Description
Recombinant Human Antibody (MOR8457) is capable of binding to PDGF-BB, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PDGF-BB mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-PDGF-BB mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
PDGFB
Target Alias Names
PDGFB, platelet-derived growth factor beta polypeptide, SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2, platelet-derived growth factor subunit B, becaplermin, PDGF, B chain, PDGF subunit B, proto-oncogene c-Sis, platelet-derived growth factor 2, platelet-derived growth factor B chain, platelet-derived growth factor, beta polypeptide (oncogene SIS), platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression