Description
Recombinant Antagonist Human Antibody (MEDI546) is capable of binding to IFNAR1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IFNAR1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IFNAR1 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
IFNAR1
Target Alias Names
IFNAR1, interferon (alpha, beta and omega) receptor 1, AVP, IFRC, IFNAR, IFNBR, IFN-alpha-REC, interferon alpha/beta receptor 1, CRF2-1, IFN-R-1, IFN-alpha/beta receptor 1, interferon-beta receptor 1, beta-type antiviral protein, alpha-type antiviral protein, type I interferon receptor 1, cytokine receptor class-II member 1, cytokine receptor family 2 member 1, interferon-alpha/beta receptor alpha chain
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression