Description
Recombinant Human Antibody (Gipg013) is capable of binding to GIPR, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-GIPR mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-GIPR mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is a specific competitive antagonist with equally high potencies to mouse, rat, dog, and human GIP receptors with a Ki of 7 nm for the human GIPr. Gipg013 antagonizes the GIP receptor and inhibits GIP-induced insulin secretion in vitro and in vivo.
Target
GIPR
Target Alias Names
GIPR, gastric inhibitory polypeptide receptor, PGQTL2, GIP-R, glucose-dependent insulinotropic polypeptide receptor
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression