Description
Recombinant Human Antibody (MEDI7814) is capable of binding to C5, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-C5 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-C5 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
C5
Target Alias Names
C5, complement component 5, C5D, C5a, C5b, ECLZB, CPAMD4, complement C5, prepro-C5, C5a anaphylatoxin, anaphylatoxin C5a analog, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression