Description
This product is a Human antibody that recognizes Human SIRPA. The "kick-off" antibody clone 115 binds SIRPα directly underneath CD47 at a site mostly independent from that of CD47, with the exception of one residue localized to the C'D loop of SIRPα, Glu54, which is shared by both 115 and CD47.
Target
SIRPA
Target Alias Names
BIT, MFR, P84, SIRP, MYD-1, SHPS1, CD172A, PTPNS1, tyrosine-protein phosphatase non-receptor type substrate 1, CD172 antigen-like family member A, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, inhibitory receptor SHPS-1, macrophage fusion receptor, myd-1 antigen, tyrosine phosphatase SHP substrate 1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression