Description
Recombinant Chimeric (Human/Mouse) Antibody (mAb6.64) is capable of binding to VEGFR2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-VEGFR2 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-VEGFR2 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The antibody bind at opposite ends of VEGFR2 domain 3 and prevent receptor dimerization by perturbing the domain 3 : domain 4 interface.
Target
KDR
Target Alias Names
KDR, kinase insert domain receptor, FLK1, CD309, VEGFR, VEGFR2, vascular endothelial growth factor receptor 2, soluble VEGFR2, fetal liver kinase 1, fetal liver kinase-1, protein-tyrosine kinase receptor Flk-1, tyrosine kinase growth factor receptor, kinase insert domain receptor (a type III receptor tyrosine kinase)
Isotype/Mimetic
Chimeric (mouse/human) IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression