Description
This product is a recombinant human antibody that is designed to target C-X-C motif chemokine ligand 12. Through its properties, the antibody has demonstrated a notable capacity to inhibit VEGF-induced angiogenesis. Its mechanism potentially involves the obstruction of CXCL12 binding to both CXCR4 and CXCR7, resulting in a heightened efficacy in inhibiting CXCL12-induced angiogenesis. The calculated binding affinity of this antibody to CXCL12 has been determined to be 3.7nM.
Target
C-X-C motif chemokine ligand 12
Target Alias Names
C-X-C Motif Chemokine Ligand 12, Pre-B Cell Growth-Stimulating Factor, Chemokine (C-X-C Motif) Ligand 12, Intercrine Reduced In Hepatomas, Stromal Cell-Derived Factor 1, SDF1, PBSF, IRH, C-X-C Motif Chemokine 12
Isotype/Mimetic
Chimeric (Mouse/Human) IgG2a
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression