Description
Recombinant Human Antibody (J16) is capable of binding to PCSK9, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PCSK9 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-PCSK9 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody, J16, potently inhibit PCSK9 binding to the LDLR extracellular domain and PCSK9-mediated down-regulation of LDLR in vitro.
Target
PCSK9
Target Alias Names
PCSK9, proprotein convertase subtilisin/kexin type 9, FH3, PC9, NARC1, LDLCQ1, NARC-1, HCHOLA3, subtilisin/kexin-like protease PC9, neural apoptosis regulated convertase 1, convertase subtilisin/kexin type 9 preproprotein
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression