Description
Recombinant Human Antibody (F0178C1) is capable of binding to ERBB2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ERBB2 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-ERBB2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody exhibits superior efficacy in blocking HER2/HER3 heterodimerization and signaling, and its use in combination with pertuzumab has a synergistic effect.
Target
ERBB2
Target Alias Names
ERBB2, erb-b2 receptor tyrosine kinase 2, NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu, receptor tyrosine-protein kinase erbB-2, herstatin, p185erbB2, proto-oncogene Neu, c-erb B2/neu protein, proto-oncogene c-ErbB-2, metastatic lymph node gene 19 protein, human epidermal growth factor receptor 2, neuro/glioblastoma derived oncogene homolog, tyrosine kinase-type cell surface receptor HER2, neuroblastoma/glioblastoma derived oncogene homolog, v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression