Description
Provided is an anti-human prostate-specific membrane antigen (PSMA) extracellular region, which adopts the phage display technology. The antibody is obtained by screening and enriching a large-storage capacity single-chain antibody library which is established by using peripheral blood mono-nuclear cells of a prostatic cancer patient through successive relaxation and rigorousness. The antibody can be solubly expressed in colon bacillus. The antibody not only can be combined with the recombinant PSMA extracellular region, but also can be combined with NEK 293 cells with PSMA expressed on surface thereof and a prostate adenocarcinoma cell LNCaP, thus laying a foundation for adopting the antibody to perform prostate adenocarcinoma image diagnosis and guiding treatment.
Target
FOLH1
Target Alias Names
Folate Hydrolase 1, N-Acetylated-Alpha-Linked Acidic Dipeptidase I, Pteroylpoly-Gamma-Glutamate Carboxypeptidase, Folylpoly-Gamma-Glutamate Carboxypeptidase, Cell Growth-Inhibiting Gene 27 Protein, Membrane Glutamate Carboxypeptidase, Glutamate Carboxypeptidase II, Glutamate Carboxypeptidase 2, Glutamate Carboxylase II, EC 3.4.17.21, NAALADase I, NAALAD1, GCPII
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression