Description
Provided is an antibody huM4TS.22 that specific for the platelet-derived growth factor receptor β. huM4TS.22 does not bind to deletion proteins containing only the first through second domains of PDGF-R β, but does bind to protein D1-3 containing the third domain, showing that the binding epitope is in the third domain. huM4TS.22 effectively inhibited the stimulation of proliferation by PDGF BB, showing the ability of these antibodies to neutralize the biological activity of PDGF BB.
Target
PDGFRB
Target Alias Names
Platelet Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor, Beta Polypeptide, Beta-Type Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Receptor 1, CD140 Antigen-Like Family Member B, PDGF-R-Beta, EC 2.7.10.1, PDGFR-Beta, PDGFR-1, PDGFR1, PDGFR, Platelet-Derived Growth Factor Receptor Beta
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression