Description
B7-H4 was highly expressed in many breast and ovarian tumors, suggesting its use as a tumor-associated antigen for these cancer types. FACS analysis demonstrated that 278M1 was capable of binding both human and mouse B7-H4.
Target
VTCN1
Target Alias Names
V-Set Domain Containing T Cell Activation Inhibitor 1, Immune Costimulatory Protein B7-H4, B7 Superfamily Member 1, B7 Family Member, H4, B7 Homolog 4, B7-H4, B7h.5, B7H4, V-Set Domain-Containing T-Cell Activation Inhibitor 1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression