Description
The antibody can effectively block the binding of CD47 to SIRP alpha, and promote the phagocytosis of immune cells to tumor cells, and has a clear therapeutic effect on leukemia model mice with CD47 positive expression, and has a significant synergistic effect in combination with targeted drugs such as EGFR.
Target
CD47
Target Alias Names
CD47 Molecule, Antigenic Surface Determinant Protein OA3, CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer), Antigen Identified By Monoclonal Antibody 1D8, Leukocyte Surface Antigen CD47, Integrin Associated Protein, Rh-Related Antigen, CD47 Glycoprotein
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression