Description
This is a recombinant chimeric IgG antibody (Mouse/Human) that specifically targets human B7-H3. The chimeric antibodies (chmAb-A) were modified into B7-H3-ADC by conjugating a B7-H3 binding domain with a cleavable auristatin E linker/payload called "vc-MMAE" (Concortis Biosystems).
Target
CD276
Target Alias Names
CD276 Molecule, CD276 Antigen, Costimulatory Molecule, B7 Homolog 3, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Isotype/Mimetic
Chimeric (Mouse/Human) IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression