Description
BI-AB is a fully human, high-affinity IgG1 mAb specific for ICAM-1. Owing to its cell surface expression, ICAM-1 is highly accessible for antibody-based therapy. Therefore, BI-AB could be an important contribution in treating the growing and clinically important group of patients with refractory and relapsed myeloma. BI-AB binds with high affinity and specificity to ICAM-1 and has significant activity against CD20-positive and CD20-negative multiple myeloma tumours in vivo. BI-AB could also inhibit tumour growth.
Target
ICAM1
Target Alias Name
Intercellular Adhesion Molecule 1
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression