Description
This is a humanized monoclonal antibody that specifically binds to an ORP150 polypeptide expressed of the cell surface of plasmacytoma, multiple myeloma, colorectal cancer cells, gastric cancer cells, or esophageal cancer cells, which is derived from murine antibody 5F4. The antibody h5F4Ac.2/v17 has significant suppressive effect on tumor growth.
Target
HYOU1
Target Alias Names
Hypoxia Up-Regulated 1, 170 KDa Glucose-Regulated Protein, 150 KDa Oxygen-Regulated Protein, GRP-170, ORP-150, Grp170
Isotypes/Mimetics
Humanized IgG3, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression