Description
This is a fully human monoclonal antibody directed to CD105. The antibody 4.37 mediates a reduction in hemoglobin content, and also mediates a reduction in CD31 staining, implying the antibody exhibits anti-angiogenic activity in vivo.
Target
ENG
Target Alias Names
Endoglin, CD105 Antigen, END, Osler-Rendu-Weber Syndrome 1, HHT1, ORW1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression