Description
The monoclonal antibody Rmut8 is derived from rituximab comprising H57DE/H102YK/L93NR mutations. Rmut8 shows strongly enhanced ADCC activity than Rituximab. The tumor killing effect of Rmut8 is significantly higher than Rituximab.
Target
MS4A1
Target Alias Names
Membrane Spanning 4-Domains A1, Membrane-Spanning 4-Domains, Subfamily A, Member 1, Leukocyte Surface Antigen Leu-16, CD20 Antigen, CD20, Bp35, Membrane-Spanning 4-Domains Subfamily A Member 1, B-Lymphocyte Cell-Surface Antigen B1, B-Lymphocyte Surface Antigen B1
Isotype/Mimetic
Chimeric (mouse/human) IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression