Description
HPAB-0239-CN is a recombinant humanized IgG antibody that specifically targets the human B7-H3 protein. The antibody has been humanized to generate an antibody HPAB-0239-CN, which offers improved therapeutic potential for human treatments. The results of the study showed that the administered Fc-modified hBRCA84D-2 antibody was able to inhibit the tumor growth of HT-1197 bladder cancer cells and A498 kidney cancer cells at all doses.
Target
CD276
Target Alias Names
CD276 Molecule, Costimulatory Molecule, CD276 Antigen, B7 Homolog 3, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression