Description
This recombinant antibody is specific for human PD-L1 protein. The antibody was derived from a hybridoma cell line that secretes a CD274-specific monoclonal antibody. The specificity and affinity of this antibody were validated by ELISA. It could block the PD-L1/PD-1 binding, effectively stimulate the secretion of the cytokine IFN-γ, and inhibit tumor growth in a tumor animal model. This product could be used in the research of immunotherapy of PD-L1-mediated diseases.
Target
CD274
Target Alias Names
B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1
Isotypes/Mimetics
Humanized IgG4, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression