Description
Full length FGFR-3 has two splice forms called FGFR-3(IIIb) and FGFR-3(IIIc) that result from alternative exons encoding the third IgG-like domain of FGFR-3. FGFR-3 also has well documented mutant forms due to errors in DNA replication or translation. Given the active role of the FGFR-3 signaling pathway in a wide range of diseases including cancer, there is a need for a mechanism by which to regulate this pathway. Provided is an isolated antibody, which specifically binds to human FGFR-3(IIIb) and FGFR-3(IIIc), or mutant forms thereof.
Target
FGFR3
Target Alias Names
Fibroblast Growth Factor Receptor 3, EC 2.7.10.1, FGFR-3, JTK4, Fibroblast Growth Factor Receptor 3 Variant 4, Achondroplasia, Thanatophoric Dwarfism, Hydroxyaryl-Protein Kinase, Tyrosine Kinase JTK4, CD333 Antigen, HSFGFR3EX, EC 2.7.10, CD333, CEK2, ACH
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression