Description
This product is a recombinant human antibody that specifically targets human CD115, a type III tyrosine kinase receptor known to be involved in various cancers and inflammatory diseases. The epitope of the predicted antibody primarily encompasses the D1 domain located in the N-terminal extracellular region of CD115, along with certain residues from the D2 domain. This antibody is a non-ligand competitive anti-CSF1R mAb, with research indicating that the Fc region plays a role in its mechanism of action, hinting at a potential scorpion effect.
Target
Colony stimulating factor 1 receptor
Target Alias Names
Colony Stimulating Factor 1 Receptor, McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog, Proto-Oncogene C-Fms, CSF-1 Receptor, CD115 Antigen, EC 2.7.10.1, M-CSF-R, CSF-1R, FMS, Macrophage Colony Stimulating Factor I Receptor
Isotype/Mimetic
Humanized IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression