Description
This is a genetically engineered recombinant human monoclonal antibody to CD38. This monoclonal antibody has demonstrated efficacy in patients when administered at specific dosage regimens. Derived from HuCAL, a human source, this IgG1 antibody exhibits effective antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). Additionally, it shows high activity in preclinical models of multiple myeloma.
Target
Cluster of differentiation 38
Target Alias Names
CD38 Molecule, ADP-Ribosyl Cyclase 1, 2-Phospho-Cyclic-ADP-Ribose Transferase, Cyclic ADP-Ribose Hydrolase 1, 2-Phospho-ADP-Ribosyl Cyclase, NAD(+) Nucleosidase, CD38 Antigen (P45), ADPRC 1, 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase, Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase
Isotypes/Mimetics
Human IgG1, λ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression