Description
The CC-chemokine receptor CCR5 is the major co-receptor for macrophage-tropic (R5) strains, and plays a crucial role in the sexual transmission of HIV-1 (4, 5, 21, 36). T cell line-tropic (X4) viruses use CXCR4 to enter target cells, and usually, but not always, emerge late in disease progression or as a consequence of virus propagation in tissue culture. Anti-CCR5 monoclonal antibodies have also shown the importance of the extracellular loops for viral entry
Target
CCR5
Target Alias Names
Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene), HIV-1 Fusion Coreceptor, CC-CKR-5, ChemR13, CMKBR5, CCR-5, C-C Motif Chemokine Receptor 5 A159A, Chemokine (C-C Motif) Receptor 5, Chemokine Receptor CCR5, CD195 Antigen, C-C CKR-5, CCCKR5, IDDM22, CD195, CKR-5, CKR5
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression