Description
Chemokine receptor 4 (also known as fusin, CD 184, LESTR or HUMSTR) exists as two isoforms comprising 352 or 360 amino acids. Targeting cancer metastases by interfering with CXCR4 receptor was demonstrated in vivo using a monoclonal antibody directed against CXCR4 receptor.
Target
CXCR4
Target Alias Names
Chemokine (C-X-C Motif) Receptor 4, Leukocyte-Derived Seven Transmembrane Domain Receptor, Lipopolysaccharide-Associated Protein 3, Stromal Cell-Derived Factor 1 Receptor, LPS-Associated Protein 3, SDF-1 Receptor, CD184 Antigen, Fusin, LAP-3, LESTR, NPYRL, FB22, HM89, LCR1, Seven-Transmembrane-Segment Receptor, Spleen, Chemokine (C-X-C Motif), Receptor 4 (Fusin), Seven Transmembrane Helix Receptor, Neuropeptide Y Receptor Y3, Neuropeptide Y3 Receptor, D2S201E, HSY3RR, NPYY3R, CXC-R4, CXCR-4, CD184, NPY3R, WHIMS, NPYR, LAP3, WHIM
Isotypes/Mimetics
Humanized IgG1, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression