Description
This product is a recombinant humanized antibody that recognizes human 4-1BB. Mab Hz4B4-1 could interfere with 4-1BB/4-1BBL interaction that plays an important role in T cell activation and could eliminate 4-1BB expressing T cells via complement-dependent cytotoxicity and antibody-dependent cellular toxicity. Hz4B4-1 could also be used for the treatment of other T-cell mediated autoimmune diseases and graft rejections.
Target
TNFRSF9
Target Alias Names
TNF Receptor Superfamily Member 9, T-Cell Antigen 4-1BB Homolog, 4-1BB Ligand Receptor, CD137 Antigen, CDw137, CD137, ILA, Interleukin-Activated Receptor, Homolog Of Mouse Ly63, Tumor Necrosis Factor Receptor Superfamily, Member 9, Hz4B4-1, MAb Hz4B4-1
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression