Description
The tumor suppressor gene p53 inhibits tumor growth primarily via induction of apoptosis. Mutations in the p53 tumor suppressor gene are the most common genetic alterations and occur in more than half of all human tumors. An isolated antibody that specifically binds an exposed epitope shared by p53 mutant proteins and not by wild type p53 protein, and can be used to diagnose a p53-related cancer.
Target
TP53
Target Alias Names
TP53, Tumor protein p53, P53, BCC7, LFS1, TRP53
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression