Description
Recombinant monoclonal antibody specially binds to A3-C1 domains of factor VIII. This human anti-F8 antibody (KM41) is dependent on residues R1803-K1818, which contain a binding site for factor IXa. In view of the similar epitope specificity of scFv KM41 and CLB-CAg A, it is likely that scFv KM41 competes with factor IXa for binding to the factor VIII light chain.
Target
F8
Target Alias Names
AHF, F8B, F8C, HEMA, FVIII, DXS1253E
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression