Description
This is a humanized antibody achieved by the transplantation of CDRs from the murine VH of the ccM4 antibody into FRs of the human myeloma protein NEWM. The humanized antibody hmM4 retained its binding reactivity for the TAG72 antigen as measured by ELISA and Western blotting analysis respectively. However, it showed considerably less immunoreactivity for the TAG72 antigen than the original chimeric antibody ccM4.
Target
TAG72
Target Alias Names
TAG-72, Tumor-associated glycoprotein 72
Isotype/Mimetic
Chimeric (mouse/human) IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression