Description
GAPDH is glycolytic enzymes essential for efficient energy production and are expressed in all prokaryotic and eukaryotic organisms. In addition to its glycolytic functions, GAPDH is a multifunctional protein endowed with diverse activities, including phosphorylating transverse-tubule proteins, stimulating RNA transcription, and influencing DNA replication and DNA repair. TPI and GAPDH have been considered to associate with brain microtubules. Anti-TPI or anti-GAPDH Abs may induce an immune hypersensitivity reaction, through activation of complements and macrophages, leading to neuronal and axonal degeneration in MS.
Target
GAPDH
Target Alias Names
G3PD, GAPD, HEL-S-162eP
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression